The Cardinals got some good players from the Padres.
- July 31, 2010: As part of a 3-team trade: The San Diego Padres sent Corey Kluber to the Cleveland Indians. The San Diego Padres sent Nick Greenwood to the St. Louis Cardinals. The Cleveland Indians sent Jake Westbrook to the St. Louis Cardinals. The St. Louis Cardinals sent Ryan Ludwick to the San Diego Padres.
- December 4, 2008: The St. Louis Cardinals traded a player to be named later and Mark Worrell to the San Diego Padres for Khalil Greene. The St. Louis Cardinals sent Luke Gregerson (March 23, 2009) to the San Diego Padres to complete the trade.
- December 14, 2007: The St. Louis Cardinals traded Jim Edmonds to the San Diego Padres for David Freese.
- March 29, 2004: The St. Louis Cardinals traded Kerry Robinson to the San Diego Padres for Brian Hunter.
- December 15, 2002: The San Diego Padres traded Brett Tomko to the St. Louis Cardinals for a player to be named later and Luther Hackman. The St. Louis Cardinals sent Mike Wodnicki (minors) (December 16, 2002) to the San Diego Padres to complete the trade.
- August 2, 2001: The St. Louis Cardinals traded Ray Lankford and cash to the San Diego Padres for Woody Williams.
- July 31, 2000: The San Diego Padres traded Nate Tebbs (minors) and Carlos Hernandez to the St. Louis Cardinals for Ben Johnson and Heathcliff Slocumb.
- June 13, 1997: The St. Louis Cardinals traded Rich Batchelor, Danny Jackson and Mark Sweeney to the San Diego Padres for Scott Livingstone, Phil Plantier and Fernando Valenzuela.
- February 27, 1990: The St. Louis Cardinals traded Alex Cole and Steve Peters to the San Diego Padres for Omar Olivares.
- April 24, 1989: The San Diego Padres traded Randy Byers to the St. Louis Cardinals for Jeremy Hernandez.
- December 10, 1981: The San Diego Padres traded a player to be named later, Steve Mura and Ozzie Smith to the St. Louis Cardinals for a player to be named later, Sixto Lezcano and Garry Templeton. The San Diego Padres sent Al Olmsted (February 19, 1982) to the St. Louis Cardinals to complete the trade. The St. Louis Cardinals sent Luis DeLeon (February 19, 1982) to the San Diego Padres to complete the trade.
- December 8, 1980: The San Diego Padres traded a player to be named later, Rollie Fingers, Bob Shirley and Gene Tenace to the St. Louis Cardinals for Terry Kennedy, John Littlefield, Al Olmsted, Mike Phillips, Kim Seaman, Steve Swisher and John Urrea. The San Diego Padres sent Bob Geren (December 10, 1980) to the St. Louis Cardinals to complete the trade.
- May 26, 1978: The San Diego Padres traded George Hendrick to the St. Louis Cardinals for Eric Rasmussen.
- May 17, 1977: The San Diego Padres traded Butch Metzger to the St. Louis Cardinals for John D’Acquisto and Pat Scanlon.
- May 19, 1976: The San Diego Padres traded Bill Greif to the St. Louis Cardinals for Luis Melendez.
- April 8, 1976: The San Diego Padres traded Danny Frisella to the St. Louis Cardinals for Robert Stewart (minors) and Ken Reynolds.
- October 20, 1975: The San Diego Padres traded Dick Sharon to the St. Louis Cardinals for Willie Davis.
- June 24, 1975: The San Diego Padres purchased Don Hahn from the St. Louis Cardinals.
- November 18, 1974: The San Diego Padres traded a player to be named later and Ed Brinkman to the St. Louis Cardinals for Rich Folkers, Alan Foster and Sonny Siebert. The San Diego Padres sent Danny Breeden (December 10, 1974) to the St. Louis Cardinals to complete the trade.
- October 25, 1973: The San Diego Padres purchased Matty Alou from the St. Louis Cardinals.
- June 7, 1973: The San Diego Padres traded Dave Campbell to the St. Louis Cardinals for Dwain Anderson.
- September 1, 1972: The San Diego Padres purchased Dennis Higgins from the St. Louis Cardinals.
- June 20, 1972: The San Diego Padres traded Rafael Robles to the St. Louis Cardinals for Bob Chlupsa and Mike Fiore. Mike Fiore returned to the original team on July 3, 1972.
- June 11, 1971: The San Diego Padres traded Al Santorini to the St. Louis Cardinals for Leron Lee and Fred Norman.
- June 15, 1970: The San Diego Padres purchased Ron Willis from the St. Louis Cardinals.
- June 15, 1970: The St. Louis Cardinals purchased Bobby Etheridge from the San Diego Padres.
- April 2, 1970: The San Diego Padres traded Billy McCool to the St. Louis Cardinals for Steve Huntz.
- May 22, 1969: The San Diego Padres traded Jerry DaVanon and Bill Davis to the St. Louis Cardinals for Sonny Ruberto and John Sipin.
- December 3, 1968: The St. Louis Cardinals traded Philip Knuckles (minors), Danny Breeden, Ron Davis, and Ed Spiezio to the San Diego Padres for Dave Giusti.